Coriolus versicolor (also known under the names Trametes versicolor, Yun Zhi, Kawaratake and Turkey Tail) is probably the most intensively researched medicinal mushroom in the world, due to its outstanding properties as a biological response modifier.
Oriveda PSP-50 is the most potent Turkey Tail extracts commercially available. It is also one of very few fully certified extract worldwide, with guaranteed levels of the main bioactive and bioavailable compounds.
Turkey Tail PSP 50
180 vegetable-capsules @ 350 mg
Recommended intake: 3 capsules p/day (2 months supply)
A leaflet with detailed instructions and background is included with every order.
> 22 % polypeptides
> 35 % beta-glucan (two different types)
> 1.4 % polyphenols
- hot water extract -
Extracted using hot water extraction followed by alcohol precipitation, identical to the original methodology.
Click here to see our authorised ‘Supplement Facts’ label.
For a more detailed third party analysis report, please click here.
Produced in compliance with the following quality standards :
ISO 9001:2008, ISO 22000:2005, HACCP, cGMP
Halal, Koosjer, USDA organic (EcoCert)
Although turkey tail grows all over the world, until recently, it's medicinal qualities have only been appreciated in China & South-East Asia. Its medicinal value as part of the Chinese traditional medicine dates back for at least 2000 years and includes general health-promoting effects, including endurance and longevity.
PSP is an abbreviation of PolySaccharidePeptide, which is a protein-bound polysaccharide derived from the COV-1® mycelium strain, known to be the most potent strain for producing PSP.
"The results of numerous studies and clinical trials confirm that PSP inhibits the growth of cancer cells in in vitro and in vivo settings as well as decreases cancer treatment-related adverse side effects such as fatigue, loss of appetite, nausea, vomiting, and pain.
PSP is able to restore weakened immune response observed in patients with cancer during chemotherapy. Its anti-tumor effects seemed to be mediated through immunomodulatory regulation."
Polysaccharidepeptide, which due to the negligible toxicity and numerous benefits for health, is increasingly used in China and Japan as an adjuvant in the treatment of cancer."
ORIVeDA’s PSP-50 is identical to the original PSP as it was developed in China, over 25 years ago. In itself PSP is an improved version of the well-known Japanese PSK, which is even older.
ORIVeDA’s PSP-50 has been cultivated and extracted using the original methods. The only difference is a significant higher purity due to the more advanced 21st century pharmaceutical techniques. Only pure COV-1® mycelium (the ‘roots’ of the mushroom) was used for the extract, having the highest level of the desired bio-active compounds.
According to the original research the most potent source of ‘PSP’ is that COV-1® mycelium strain, which should ideally have been cultivated using so-called ‘deep layer cultivation’ (growing it in sterile laboratory tanks, in liquid substrate). This technique is standard in China but hardly used anywhere else, due to the high cost.
Cheap cultivation techniques are using rice/grains to grow mushrooms (solid substrate), but since it is impossible to isolate the spiderweb-like mycelium from the substrate in the end the final product is in fact ‘biomass’, not mushroom. It is contaminated with undigested substrate in the form of starch; levels can be as high as 80% (!).
Such products are not per definition without potential but in general their actual therapeutic effects are low and the value for money is poor. On top of that these products are in general not extracted, rendering them even less useful. They do not specify any bioactive compounds on their labels and a 2016 test report showed many of these product contained no beta-glucan at all, only starch(!!). Research found that the immunological effects of mushroom extracts are up to 10 times higher when compared against non-extracted powders.
Scientific research uses in general specialised, highly concentrated extracts to investigate the effects of these mushrooms. ORIVeDA extracts are comparable in both composition and quality, so the research results you read about you can also expect from our extracts.
Extracted using hot water followed by alcohol precipitation - the main bioactives are water-solubles with a high molecular weight according to research. Alcohol precipitation is a purification process. It removes useless matter and low molecular weight compounds and thus increases the concentration of bioactive compounds in the final product. The final product contains no alcohol.
An objective and easy-to-follow mushroom supplement shopping-guideline here. Includes good to know key points when shopping for mushroom supplements.
The effects in the body, when described in brief, are as follows. Turkey Tail PSP works on the immune system, so most (but not all) of its workings are indirect. It increases the number of white blood cells when this is too low, it will stimulate the creation and the activity of macrophages, T-cells (including T-helper cells, cytotoxic T-cells and lymphocytes) and NK (natural killer)-cells, all of which are part of the body’s defence system against pathogens. It has both direct and indirect anti-inflammatory, anti-viral and detoxing properties and supports the liver function (our body’s chemical processing plant).
Many patients have taken PSP consecutively for a decade or more and no adverse effect or contraindication has ever been found.
For a very interesting study, please click here to view Solomon Habtemariam's 2020 article in the Biomedicines journal: Trametes versicolor Synn. Coriolus versicolor. Polysaccharides in Cancer Therapy: Targets and Efficacy
Our PSP-50 is very popular with dog-owners because research (based on a similar product) showed good effects when used for dogs with cancer. Our product is cheaper and contains more active compounds than the researched product.
In the research the best results were achieved with a daily dosage of 100mg p/kg of bodyweight. Higher dosages were not investigated but might even be more effective, given that the therapeutic effects are dose-dependant.
Using the research report as a guideline the recommended dosage for our PSP-50 product is ± 70mg daily p/kg bodyweight. One capsule contains 350 mg.
TURKEY TAIL RESEARCH ARTICLES