Peer reviewed articles about Medicinal Mushrooms

• "Medicinal mushrooms have important health benefits and exhibit a broad spectrum of pharmacological activities, including antiallergic, antibacterial, antifungal, anti-inflammatory, antioxidative, antiviral, cytotoxic, immunomodulating, antidepressive, antihyperlipidemic, antidiabetic, digestive, hepatoprotective, neuroprotective, nephroprotective, osteoprotective, and hypotensive activities"

(2021) Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials

• "Medicinal mushrooms and their extract have a large number of bioactive components called secondary metabolites. The presence of polysaccharide β-glucans or polysaccharide–protein complexes content in mushroom extract have great therapeutic applications in human health as they possess many properties such as anti-diabetic, anti-cancerous, anti-obesity, immunomodulatory, hypocholesteremia, hepatoprotective nature along with anti-aging."

(2018) Medicinal mushroom: boon for therapeutic applications

• Stress, emotion, and human immune function

  Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry

• Enhancing versus Suppressive Effects of Stress on Immune Function: Implications for Immunoprotection versus Immunopathology

• Polysaccharide Immunomodulators as Therapeutic Agents

• The effects of β-glucan on human immune and cancer cells

• Beta-Glucans History and the present - Immunomodulatory aspects and Mechanisms of action

• Stress, emotion, and human immune function

• Betulinic Acid for Cancer Treatment and Prevention
• Betulinic Acid Inhibits Prostate Cancer Growth through Inhibition of Specificity Protein Transcription Factors
• Betulinic Acid and Its Derivatives: A Review on their Biological Properties
• The Western approach to Medicinal Mushrooms
• Immunomodulation by dietary mushroom compounds
• Medicinal mushroom modulators of molecular targets as cancer therapeutics
• Immunobiology of Mushrooms
• Medicinal mushrooms and pets
• Biological and Pharmacological Activity of Higher Fungi: 20-Year Retrospective Analysis
• Mushrooms as a functional food mediator in preventing and ameliorating diabetes
• Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans
• Recent developments in mushrooms as anti-cancer therapeutics- a review

• "H. erinaceus may supply neuroprotective metabolites to be used as valuable, effective candidates for treating and preventing age-related neurodegenerative diseases." (2021) Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging

   

•  "The extracts thus could be used to treat oxidative stress-related disorders as they are found to contain antioxidant compounds like phenols and others and also they possessed good antimicrobial and anticancer activity." (2021) Prospecting medicinal properties of Lion's mane mushroom   

• "In particular, they seem to act on microglia and consequently on the NF-κB pathway, reducing the neuroinflammation that spreads from the cortex to other areas of the brain." (2021) Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury

   

• "In conclusion, our study showed that 4 weeks of intraperitoneal administration of HE alleviated depressive-like behaviours in a CRS model of depression." (2021) Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression

   

•  "...a significant improvement in Mini-Mental State Examination score was observed in the EAHE group and a significant Instrumental Activities of Daily Living score difference were found between the two groups." (2020) Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study

• "The pre-clinical and clinical studies have demonstrated that H. erinaceussignificantly ameliorates depressive disorder through monoaminergic modulation, neurogenic/neurotrophic, and anti-inflammatory pathway. (2019) Therapeutic Potential of Hericium erinaceus for Depressive Disorder

• We speculate that various chemical compounds, including hericenones, in the mushroom have multiple effects to the brain neural networks and improve cognitive functions. Oral intake of H.erinaceus is safe and convenient method for dementia prevention so far. (2019) Improvement of cognitive functions by oral intake of Hericium erinaceus

• "The mechanisms of neuroprotection were through the improvement of antioxidant, mitochondrial function and anti-apoptosis."  (2019) Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia

•  "...the majority of preclinical data strongly suggests that it is safe and offers much-needed neuroprotective applications." (2018) Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines

• "Over the past decade, it has been demonstrated that H. erinaceus polysaccharides possess various promising bioactivities, including antitumor and immunomodulation, anti-gastric ulcer, neuroprotection and neuroregeneration, anti-oxidation and hepatoprotection, anti-hyperlipidemia, anti-hyperglycemia, anti-fatigue and anti-aging." (2017) Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom: A review

• "The reported health-promoting properties of the mushroom fruit bodies, mycelia, and bioactive pure compounds include antibiotic, anticarcinogenic, antidiabetic, antifatigue, antihypertensive, antihyperlipodemic, antisenescence, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties and improvement of anxiety, cognitive function, and depression." (2015) Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds 

   
• Hericium erinaceus- an edible mushroom with medicinal values 
• Effects of cultivation techniques and processing on antimicrobial and antioxidant activities of Hericium erinaceus 
• Compounds for dementia from Hericium erinaceum
• Reversal of cognitive decline: A novel therapeutic program 
• Hericenones and erinacines- stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus
• Reduction of depression and anxiety after 4 weeks of Lion's Mane intake 
• Functional Recovery Enhancement Following Injury to Rodent Peroneal Nerve by Lion’s Mane Mushroom, Hericium erinaceus
• Hypoglycemic effect of extract of Hericium erinaceus
• The influence of Hericium erinaceus extract on myelination process in vitro
• Protective Effects of Hericium erinaceus Mycelium and Its Isolated Erinacine A against Ischemia-Injury-Induced Neuronal Cell Death
• Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress 
• Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies
• Cyanthin Diterpenoid and Sesterterpene Constituents of Hericium erinaceus Mycelium Ameliorate Alzheimer’s Disease-Related Pathologies
• Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain

• "The findings conclude that the T. versicolor could be an alternative source for CNS anti-depressant and antioxidant activity." (2021) Deciphering the CNS anti-depressant, antioxidant and cytotoxic profiling of methanol and aqueous extracts of Trametes versicolor and molecular interactions of its p​henolic compounds

   

• "T. versicolor chitosan/PVA nanofibers have good potential for use as wound dressings." (2021) In vivo and in vitro evaluation of the wound healing properties of chitosan extracted from Trametes versicolor

   

• "C. versicolor have now been established to induce direct cytotoxicity to cancer/tumour cells. They also increase the release of cytokines such as TNF-α with direct implication to tumour cell killing." (2020) Trametes versicolor Polysaccharides in Cancer Therapy: Targets and Efficacy

   

• "We conclude that the Coriolus Versicolor extract possesses cytotoxic activity against cancer cells and endothelial cells and has the ability to inhibit the expression of the pro-tumorigenic factors associated with inflammation." (2020) Extract from the Coriolus versicolor Fungus as an Anti-Inflammatory Agent with Cytotoxic Properties against Endothelial Cells and Breast Cancer Cells

   

  "PSP was approved by the authority and has been used clinically in Japan and China since 1970s. PSP is helpful in improving the survival and quality of life in patients suffering cancers, hepatopathy, hyperlipidemia, chronic bronchitis, and other complex diseases." (2019) Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China

   

• "The results of numerous studies and clinical trials confirm that it inhibits the growth of cancer cells in in vitro and in vivo settings as well as decreases cancer treatment-related adverse side effects such as fatigue, loss of appetite, nausea, vomiting, and pain. PSP is able to restore weakened immune response observed in patients with cancer during chemotherapy. Its anti-tumor effects seemed to be mediated through immunomodulatory regulation. PSP stimulates cells of the immune system" (2015) Immunomodulatory and antitumor properties of polysaccharide peptide (PSP)

   

• (2014) Control of oral human papillomavirus (HPV) by medicinal mushrooms, Trametes versicolor and Ganoderma lucidum: a preliminary clinical trial

   

• "...contains putative prebiotic agents that alter human gut microbiota and pH. This prebiotic-like activity may help explain some of the plethora of the health benefits attributed to this traditional Chinese medicine." (2013) Trametes versicolor Extract Modifies Human Fecal Microbiota Composition In vitro

   

• (2011) Coriolus versicolor suppresses inflammatory bowel disease by Inhibiting the expression of STAT1 and STAT6 associated with IFN-γ and IL-4 expression

• PSP in clinical cancer therapy - A brief overview of Phase I, II and III trials

• The Use of Mushroom Glucans and Proteoglycans in Cancer Treatment

• Chemopreventive Effect of PSP Through Targeting of Prostate Cancer Stem Cell-Like Population

• Clinical Implications of PSP in Oncology

• Coriolus versicolor - Detailed Scientific Review - MD Anderson Cancer center

• General review of polysaccharopeptides (PSP) from C. versicolor: Pharmacological and clinical studies - Cancer Therapy

• Oral coriolus versicolor polysaccharide peptide is beneficial by slowing the progression of lung cancer

• Polysaccharopeptides of Coriolus versicolor: physiological activity, uses, and production

• "The patient experienced positive effects of self-medication without experiencing adverse effects" (2021) Self-Medication with Ganoderma lucidum (“Reishi”) to Combat Parkinson's Disease Symptoms: A Single Case Study

• "..used in the treatment of cancer and the regulation of the human immune system. Recently, this mushroom has been used as an eco-friendly reducing agent in the green mycosynthesis of metallic nanoparticles." (2021) Ganoderma lucidum: King of Mushroom

• "Accumulated studies have demonstrated that the Ganoderma modulates immune function both in vivo and in vitro."                                                                                                                                                                                               (2019) Immunomodulating Effect of Ganoderma (Lingzhi) and Possible Mechanism

• "Preclinical and clinical studies have demonstrated that GLP not only has anti-proliferative, pro-apoptotic and anti-migratory effects on cancer cells, but also possesses anti-angiogenic and immunomodulatory effects. Hence, combined use of GLP could be beneficial to cancer patients receiving conventional chemotherapy and/or radiotherapy, and help improve patient’s immune function and alleviate the toxicity of conventional therapy. Moreover, according to literatures, it appears to be safe." (2019) Ganoderma lucidum Polysaccharides as an anti-cancer agent

• "...G. lucidum prevented from heart damage in a variety of disease models, such as streptozotocin (STZ)-induced diabetic, high-fat-diet-induced diabetic, isoprenaline (ISO)-induced myocardial hypertrophy, acute ethanol-induced heart toxicity, and transverse aortic constriction (TAC) models." (2019) Protective Effect of Ganoderma (Lingzhi) on Cardiovascular System

•  "...recently revealed to improve skin quality and treat skin diseases.                                                                           (2019) Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Skin Diseases and Care

• "Recently, many lines of studies have elucidated the therapeutic effects of G. lucidum and its extractions on various acute kidney injury (AKI) and chronic kidney disease (CKD) pathogenesis, including autosomal dominant polycystic kidney disease, diabetic nephropathy, renal proximal tubular cell oxidative damage and fibrotic process, renal ischemia reperfusion injury, cisplatin-induced renal injury, adriamycin-induced nephropathy, chronic proteinuric renal diseases, etc."                                                                                                                                                                  (2019) Preventive and therapeutic effect of Ganoderma lucidum on kidney injuries and diseases

•  "...approved by the Chinese FDA as Polysacharidum of G. lucidum Karst Injection in 2000, which is applied intramuscularly. After more than 40 years of clinical use, its efficacy, safety, and long-term tolerability have been recognized by neurologists. It is one of a few non-hormonal drugs used for treating neurosis, polymyositis, dermatomyositis, atrophic myotonia and muscular dystrophy." 
  (2019) Ganoderma lucidum polysaccharide used for treating physical frailty in China 

• (2019) Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Diabetes

• "Ganoderma lucidum comprises probably 400 different biologically active constituents... which have been proved to have several therapeutical properties to control various diseases."                                                                                    (2018) Ganoderma lucidum: Persuasive biologically active constituents and their health endorsement

• (2015) Triterpenoids and Polysaccharide Fractions of Ganoderma tsugae Exert Different Effects on Antiallergic Activities
• Ganoderma - A therapeutic fungal biofactory
• Reishi or Ling Zhi (Ganoderma lucidum) 
• Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom
• Biologically active metabolites of the genus Ganoderma - 3 decades of myco-chemistry research
• Effect of thirty days supplementation of standardized LingZhi extract on aerobic, anaerobic and strength parameters in trained athletes 
• Ganoderma lucidum (‘Lingzhi’), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study
• Reishi Mushroom as a Hayfever Remedy
• Cat Allergy Alleviated with Reishi
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• "Inonotus obliquus exhibited enormous potential in immunity enhancement, and antitumor, antioxidant, anti-fatigue, hypoglycemic, and hypolipidemic activity, providing an alternative way for treatment of cancer and diabetes." (2021) Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application

• "Chaga mushroom shows promise in interacting with the viral spike protein and can be further explored in clinical settings that can bolster the current treatment regime for SARS‐CoV‐2. This will assist in developing natural anti‐coronavirus therapeutics in future that can greatly supplement the use of current anti‐SARS‐CoV‐2 drugs." (2021) Targeting SARS‐CoV‐2 with Chaga mushroom: An in silico study toward developing a natural antiviral compound

• "The findings uncovered the benefits of Chaga mushroom on DNA damage and advocated its use and development as a natural therapeutic.      "                                                                                                                                       (2021) Chaga mushroom (Inonotus obliquus) polysaccharides exhibit genoprotective effects in UVB-exposed embryonic zebrafish (Danio rerio) through coordinated expression of DNA repair genes

• "...inonotusols I and L presented the most potent inhibitory effects on inducible nitric oxide synthase (iNOS) and NO production without any significant cytotoxicity"                                                                                                      (2021) Anti-neuroinflammatory polyoxygenated lanostanoids from Chaga mushroom Inonotus obliquus

• "It provides the theoretical basis and evidence for preventing and treating T. gondii infection with Inonotus obliquus"                                                                                                                                                                                      (2021) Inhibitory Effects of Inonotus obliquus Polysaccharide on Inflammatory Response in Toxoplasma gondii-Infected RAW264.7 Macrophages

• "...for those who are in the process of chemotherapy administration of the fungus will not only chemosensitize the tumor cells and thereby increasing the chemotherapeutic effects, but also help to restore the compromised immunity and protect against ulcerative GI tract damage and other side-effects induced by chemotherapy."                                                                                                                                                                (2020) Deciphering the antitumoral potential of the bioactive metabolites from medicinal mushroom Inonotus obliquus

• "Data presented here supports that histamine induced inflammation is a major disruptor of junctional integrity, and highlights the important anti-inflammatory properties of Inonotus obliquus"                                                                                                                                                                (2019) Inonotus obliquus attenuates histamine-induced microvascular inflammation
• Treatment of psoriasis with Chaga

• Antioxidant Small Phenolic Ingredients in Inonotus obliquus
• Identification of Inonotus obliquus (Chaga) and Analysis of Antioxidation and Antitumor Activities of Polysaccharides
• Sterol composition in field-grown and cultured mycelia of Inonotus Obliquus
• Chemical and pharmacological properties of dry extract from black birch fungus
• Antitumor Activity of Water Extract of a Mushroom, Inonotus obliquus, against HT-29 Human Colon Cancer Cells 
• Antioxidant effect of Inonotus obliquu
• Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract
• Analysis of an aqueous extract of Inonotus Obliquus (Chaga)
• The Anticancer Effect of Inonotus obliquus Pilat (Chaga) Processed by Nanomill Technology In vivo 
• Chemical and medico-biological properties of Chaga
• Fungal medicine, Fuscoporia obliqua (Chaga), as a traditional herbal medicine: its bioactivities, in vivo testing and medicinal effects
• Phenolic compounds from Inonotus obliquus and their immune-stimulating effects
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• "Cordycepin is known for various nutraceutical and therapeutic potential, such as anti-diabetic, anti-hyperlipidemia, anti-fungal, anti-inflammatory, immunomodulatory, antioxidant, anti-aging, anticancer, antiviral, hepato-protective, hypo-sexuality, cardiovascular diseases, antimalarial, anti-osteoporotic, anti-arthritic, cosmeceutical etc. which makes it a most valuable medicinal mushroom for helping in maintaining good health."  (2020) Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus Cordyceps with Its Nutraceutical and Therapeutic Potential

• "...our results suggest that Cs-4 has the potential to alleviate immune hypersensitivity reactions in allergic rhinitis and asthma." (2020) Anti-Inflammatory Effects of a Cordyceps sinensis Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma

• "Recently, an increasing number of studies have demonstrated the potential of Cordyceps as a therapeutic agent for the effective treatment of metabolic-related disorders by exerting a variety of activities, including but not limited to anti-inflammatory, immunoregulatory, hypoglycemic, renoprotective and cardiovascular-protective effects." (2020) The potential application of Cordyceps in metabolic-related disorders

• "...show immunomodulatory, antioxidant, antitumor, cytotoxic, anti-inflammatory, anti-allergic, antidiabetic, analgesic, anti-HIV, antibacterial, antimalarial and antifungal activities." (2018) The genus Cordyceps: An extensive review of its traditional uses, phytochemistry and pharmacology

• "In conclusion, the present study demonstrated that C. sinensis attenuated airway remodeling in rats with COPD by inhibiting airway inflammation and the TGF-β1/Smad signaling pathway. These findings suggest C. sinensis may be a useful approach for COPD therapy." (2018) Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease

• "Cordyceos Sinensis may modulate the chemotaxis of Th22 cells to suppress inflammatory responses in IgA nephropathy. " (2018) Cordyceps sinensis may inhibit Th22 cell chemotaxis to improve kidney function in lgA nephropathy

• "...Cordyceps sinensis improved the HR-QOL, asthma symptoms, lung function, and inflammatory profile of the patients with moderate-to-severe asthma." (2016) Herbal Medicine Cordyceps sinensis Improves Health-Related Quality of Life in Moderate-to-Severe Asthma

•  "Current evidence shows that cordyceps as an adjuvant to routine immunosuppressant therapy may benefit kidney transplant patient." (2016) Efficacy of Cordyceps sinensis as an adjunctive treatment in kidney transplant patients: A systematic-review and meta-analysis

• "C. sinensis not only possesses preventive but also therapeutic potentials in the treatment of lung fibrosis, and that one of its active ingredient, cordycepin, can partially reverse TGF-β1-induced epithelial–mesenchymal transition in A549 alveolar epithelial cells." (2012) Protective roles of Cordyceps on lung fibrosis in cellular and rat models                 

• The results suggested that Cordyceps sinensis and Cordyceps militaris extracts may affect the anion movement from the basolateral to apical compartments in the airway epithelia. (2008) Effects of Cordyceps sinensis, Cordyceps militaris and their isolated compounds on ion transport in Calu-3 human airway epithelial cells

• The scientific rediscovery of an ancient Chinese herbal medicine- Cordyceps sinensis: part 1
• The scientific rediscovery of an ancient Chinese herbal medicine- Cordyceps sinensis; part 2 
• Pharmacological Functions of Chinese Medicinal Fungus Cordyceps sinensis and Related Species
• Quality control of Cordyceps sinensis, a valued traditional Chinese medicine
• Effects of a supplement designed to increase ATP levels on muscle strength, power output, and endurance
• Effects of a supplement designed to increase ATP levels on muscle strength, power output, and endurance
• Genetic diversity of Ophiocordyceps sinensis, a medicinal fungus endemic to the Tibetan Plateau: Implications for its evolution and conservation
• Last Stand for the Body Snatcher Of the Himalayas?
• Cordyceps sinensis - Health Supplement Enhances Recovery from Taxol-Induced Leukopenia

• "With increasing public concern about health threats from food contamination, environmental pollution and new infectious organisms such as the COVID-19 virus, the protection of human health through the immunomodulatory and health-promoting functions of G. frondosa constituents is even more attractive and promising." (2021) Bioactive Ingredients and Medicinal Values of Grifola frondosa (Maitake) 

• "Grifola frondosa is a potential candidate for tumor treatment and clinical trials."                                              (2021) Antitumor activities of Grifola frondosa (Maitake) polysaccharide: A meta-analysis based on preclinical evidence and quality assessment

• "Grifola frondosa (GE) extract has been demonstrated to represent an important source of polysaccharides and phenolic compounds with in vitro antioxidant activity. The extract of GE was considered nongenotoxic in a preliminary SOS/umu screening test. The in vivo evaluation demonstrated that treatment with GE significantly reduced the lipid content in C. elegans, decreased the intracellular ROS accumulation and the aging-related lipofuscin pigment, and increased the nematode lifespan"                                                                                                        (2021) Grifola frondosa (Maitake) Extract Reduces Fat Accumulation and Improves Health Span in C. elegans through the DAF-16/FOXOand SKN-1/NRF2 Signalling Pathways
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• "These metabolites exerted positive effects on colorectal cell lines, in particular protecting from reactive oxygen species."                                                                                                                                                             (2021) Prebiotic Effect of Maitake Extract on a Probiotic Consortium and Its Action after Microbial Fermentation on Colorectal Cell Lines
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• "In conclusion, from the literature it seems possible that the related medicinal Basidiomycetes mushrooms, Agaricus blazei Murill, Hericium Erinaceus and Grigola Frondosa would have merit as prophylactic or therapeutic add‐on remedies in COVID‐19 infection, especially as countermeasures against a pneumococcal superinfection, even when caused by multi‐resistant bacteria, as well as for the immune overreaction and damaging inflammation that occurs with COVID‐19 attack.                                                                                                                                (2020) Can medicinal mushrooms have prophylactic or therapeutic effect against COVID‐19 and its pneumonic superinfection and complicating inflammation?
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• "Maitake mushroom beta-glucan, a dietary supplement, stimulates hematopoietic progenitor cell differentiation, granulocyte colony-stimulating factor production, and recovery of peripheral blood leukocytes after bone marrow injury."                                                                                                                                               (2015) Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study   
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• " Maitake Grifola extract alone may induce ovulation in PCOS patients and may be useful as an adjunct therapy for patients who failed first-line CC treatment."                                                                                             (2010) Maitake Mushroom Grifola frondosa Extract Induces Ovulation in Patients with Polycystic Ovary Syndrome: A Possible Monotherapy and a Combination Therapy After Failure with First-Line Clomiphene Citrate
• Can Maitake MD-Fraction Aid Cancer Patients
• Immunostimulating properties of two different β-glucans isolated from Maitake mushroom
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• "Agaricus blazei Murrill species has proven antitumor activity for some types of cancer, and the use of this natural product can improve health and increase the patients' immunity" (2022) Agaricus blazei Murrill mushroom: A review on the prevention and treatment of cancer

• "A. blazei is used to cure dermatitis, hepatitis, diabetes, therosclerosis, hyperlipidemia, and cancer in traditional medicine." (2021) Traditional Uses, Phytochemistry and Biological Activities of Agaricus blazei murrill: A Comprehensive Review

• " Sulfated modification of AbM polysaccharides can increase their anti-HIV pharmacological activity, which makes them promising alternative candidates as bioactive macromolecules for biomedical applications in HIV/AIDS."  (2021) Chemically Sulfated Polysaccharides from Agaricus blazei Murill: Synthesis, Characterization and Anti-HIV Activity

• (2021) Antiparkinsonian Activity of Aqueous Extract of Agaricus Blazei Murill in Rotenone-induced Parkinson’s Disease

• "The results suggested that ABM treatment could effectively reduce oxidative stress and contribute to pancreatic tissue recovery." (2020) The beneficial effects of Agaricus blazei Murrill on hepatic antioxidant enzymes and the pancreatic tissue recovery in streptozotocin-induced diabetic rats

• "The fruiting body of AbM is rich in β-glucans, and the biological effect of AbM has originally been attributed to the immunomodulating effect of this polysaccharide, mainly through activation of the innate immune system" (2020) Antitumor, Anti-inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies

• The Mushroom Agaricus blazei Murill in Combination with Metformin and Gliclazide Improves Insulin Resistance in Type 2 Diabetes - A Randomized, Double-Blinded, and Placebo-Controlled Clinical Trial 
• Effect of Agaricus blazei Murill on the Pulmonary Tissue of Animals with Streptozotocin-Induced Diabetes
• Agaricus blazei: cultivation and mycochemical contents

• "...results demonstrate that humic materials represent a rich source of highly potent and polytargeted natural compounds which might be used for prevention and treatment of viral infections." (2021) Antiviral activity of natural humic substances and shilajit materials against HIV-1: Relation to structure

• "Our results showed that Mumio was significantly more cytotoxic to urinary bladder cancer cells than to normal cells. These results are promising and indicate Mumio as a great candidate for urinary bladder cancer treatment and further investigations should be performed."  (2021) Mumio (Shilajit) as a potential chemotherapeutic for the urinary bladder cancer treatment

• "These findings show that Ferulic Acid is a novel therapeutic agent for wound healing that acts via inhibition of β-catenin in keratinocytes and by activation of Nrf2 in wound-induced inflammation." (2021) Ferulic Acid Induces Keratin 6α via Inhibition of Nuclear β-Catenin Accumulation and Activation of Nrf2 in Wound-Induced Inflammation

• "‏Shilajit is used commonly as Ayurvedic medicine worldwide which is Rasayana herbo-mineral substance and consumed to restore the energetic balance and to prevent diseases like cognitive disorders and Alzheimer. Locally, Shilajit is applied for patients diagnosed with bone fractures. For safety of the patients, the elemental analysis of Shilajit is imperative to evaluate its nutritional quality as well as contamination from heavy metals."  (2021) Rapid Determination and Quantification of Nutritional and Poisonous Metals in Vastly Consumed Ayurvedic Herbal Medicine (Rejuvenator Shilajit) by Humans Using Three Advanced Analytical Techniques

• "Shilajit is a commonly used Tibetan medicine, and its water extract is mainly used for various heat-related syndrome, especially that of stomach, liver and kidney. Shilajit is found to exudate from rocks of cliff at an altitude of 2000–4000m" (2020) Mechanisms of generation and exudation of Tibetan medicine Shilajit (Zhaxun)

• "Mummy (Iranian pure shilajit) triggers inhibition of EMT and metastasis in breast cancer cells mainly through the downregulation of TGFβ1 activity, and more studies required to find its specific anticancer activity with details" (2020) Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells

• "Shilajit enriched diets significantly increased the growth performance, innate immune response, and disease resistance in O. mossambicus against A. hydrophila infection." (2018) Protective efficacy of Shilajit enriched diet on growth performance and immune resistance against Aeromonas hydrophila in Oreochromis mossambicus

• "Results thus suggest the potent androgenic nature of Shilajit and its role in fertility improvement against cadmium-induced infertility." (2018) Profertility effects of Shilajit on cadmium-induced infertility in male mice

• "...resulted in skeletal muscle adaptation through upregulation of ECM-related genes that control muscle mechanotransduction properties, elasticity, repair, and regeneration." (2016) The Human Skeletal Muscle Transcriptome in Response to Oral Shilajit Supplementation

• "Treatment with Shilajit for consecutive 90 days revealed that it has significantly (P < 0.05) increased total testosterone, free testosterone and dehydroepiandrosterone (DHEAS) compared with placebo." 
  (2016) Clinical evaluation of purified Shilajit on testosterone levels in healthy volunteers

• "Many therapeutic properties have been ascribed to it, a number of which have been verified by modern scientific evaluation. Shilajit has been attributed with many miraculous healing properties."                                                                                                                                           (2007) Shilajit: a review

• The antioxidant-genoprotective mechanism of the action of the preparation Mumiyo-Vitas

• Complement-fixing Activity of Fulvic Acid from Shilajit

• Chemistry of Shilajit, an immunomodulatory Ayurvedic rasayan

• Shilajit (Mumijo) : Unraveling the mystery

• SHILAJIT - a Materia Medica monograph

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