Lion’s Mane contains over 70 bioactive ingredients.
Both the fruiting body & mycelium have health-promoting properties
ORIVeDA offers a world leading formulae of Lions Mane supplement, 100% in line with all existing research: clinical, in vivo and in vitro. The key bio-actives are all specified and quantified; and their presence, percentage and bio-availability is guaranteed.
Although Lion's Mane has been used for thousands of years for both culinary and medicinal purposes in China & other Asian cultures, Lion's Mane has only gained attention from Western science in the last few decades. The research coming out from around the world is astounding, there is huge potential for Lion's Mane
Your body's cells divide and replicate by undergoing a process called mitosis. Brain cells do not regenerate like this, instead they need the assistance of Nerve Growth Factor (NG), a secreted protein that is important for the growth, maintenance, survival and regeneration of nerve cells in the human body, and is considered critical for their survival. Without it, these nerve cells / neurons will decline and die, causing both cognitive and motoric problems.
NGF was discovered in the 1950s, and in 1986 the scientists responsible received the Nobel Prize for this discovery
It was observed that those suffering from Alzheimer's and Dementia had significantly decreases levels of NGF.
It was thought that by administering Nerve Growth Factor to patients that their NGF levels would improve, however the body is often more complex than anticipated and the Blood Brain Barrier did not let the NGF molecules through!
Lion’s Mane contains several compounds that appear to stimulate NGF production to a certain extent.
Its main effect however appears to be slowing down the decline of the nerve system due to age.
The main compounds responsible are alcohol-soluble terpenoids, and these are classified in two groups:
• Hericenones (found in the fruiting body)
• Erinacines (found in the mycelium)
These are so far the only active substances found in natural products that can induce the production of the NGF and the related BDNF (Brain-Derived Neurotropic Factor). These bioactives therefore might have great potential for -indirectly- repairing neurological damage, improving cognition and reflexes and, even more significant, to help slowing down the development of neurodegenerative diseases such as Alzheimer’s(!!)
Oriveda's L+ is a combination of two separate supplements that reinforce and complement each other, and which can be mixed, dosed and balanced against each other according to your own liking.
This can cover 2 - 4 months (depending on personal dosing preferences)
180 v-caps @ 300 mg (recommend 3 caps per day, 2 months supply)
(1:1 lossless water extract)
Contains sterols, diterpenoids, hericenone A-J, Hericene A-C,Hericerin, Erinacerin A+B
> 40 % Beta-glucans
Contains the full Lion's Mane fruiting body in a bioavailable form. Nothing was filtered out, both soluble and insoluble bio-actives are still present in their natural synergy. In this case 'lossless' is crucial because we want the product to be 100% in line with the existing clinical research.
The clinical studies noticed significant effects on cognition, moderate depression and anxiety. Usually hericenones are pointed out as being responsible for the NGF-inducing effects of the fruiting body. However, there is also research explicitly stating that hericenones have zero effect on cognition / NGF-induction.
So it is possible there might be other yet unknown bioactive compounds or synergetic combinations of compounds responsible for the observed effects. It therefore makes sense to use an unfiltered (lossless) 1:1 full-spectrum extract in this case; all fruiting body compounds are present in a bioavailable form.
Includes 120 vegetable capsules @ 450 mg (recommend 2 caps per day)
Contains sterols, diterpenoids, erinacine A-R,erinacol
>10 % Beta-Glucans>
>1.9 % Polyphenols
Oriveda 's pharmaceutical grade mycelium extract is the worlds first and (currently) the only alcohol extract based on pure liquid-grown mycelium. The emphasis is on the alcohol-soluble terpenes / terpenoids; i.e. a group of diterpenes known as erinacines.
Erinacines are seen as the most powerful NGF-inducers in Lion's Mane. They are only found in the mycelium. We have used a custom composition (a nutrients formula) for the liquid substrate in which the mycelium is growing; its purpose is to increase the production of erinacines, i.e. erinacine A.
Most products use mycelium grown on grains or rice (biomass). Because the mycelium is so fine, it cannot be separated from the starch in the grains/rice upon extraction and therefore have a low therapeutic potential. If a company lists polysaccharide as a bioactive ingredient, keep in mind starch is also a polysaccharide, but without therapeutic potential.
Produced in compliance with the following quality standards :
ISO 9001:2008, ISO 22000:2005, HACCP, cGMP
Halal, Koosjer, USDA organic (EcoCert)
Some very sensitive people might experience mild side effects due to their genetic wiring. A minute number of people using concentrated water extracts in high dosage have reported a lessening of libido. Research has never reported such side effects.
Caution: mushroom extracts with a high level of beta-glucans should never be used together with immune-suppressants, like those prescribed after a transplant.
The blood sugar lowering effects can cause fatigue in those that are highly susceptible. In general these people are also very susceptible to e.g. caffeine and alcohol, or are diabetic. Diabetics might have to adjust their medication; it’s best to discuss this with a medical professional.
Research Articles on Lion's Mane
"Hericenone B had a strong anti-platelet activity and it might be a novel compound for antithrombotic therapy possessing a novel mechanism."