"H. erinaceus may supply neuroprotective metabolites to be used as valuable, effective candidates for treating and preventing age-related neurodegenerative diseases." (2021) Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging
"The extracts thus could be used to treat oxidative stress-related disorders as they are found to contain antioxidant compounds like phenols and others and also they possessed good antimicrobial and anticancer activity." (2021) Prospecting medicinal properties of Lion's mane mushroom
"In particular, they seem to act on microglia and consequently on the NF-κB pathway, reducing the neuroinflammation that spreads from the cortex to other areas of the brain."
(2021) Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury
"In conclusion, our study showed that 4 weeks of intraperitoneal administration of HE alleviated depressive-like behaviours in a CRS model of depression." (2021) Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression
"...a significant improvement in Mini-Mental State Examination score was observed in the EAHE group and a significant Instrumental Activities of Daily Living score difference were found between the two groups." (2020) Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study
"The pre-clinical and clinical studies have demonstrated that H. erinaceussignificantly ameliorates depressive disorder through monoaminergic modulation, neurogenic/neurotrophic, and anti-inflammatory pathways" (2019) Therapeutic Potential of Hericium erinaceus for Depressive Disorder
We speculate that various chemical compounds, including hericenones, in the mushroom have multiple effects to the brain neural networks and improve cognitive functions. Oral intake of H.erinaceus is safe and convenient method for dementia prevention so far. (2019) Improvement of cognitive functions by oral intake of Hericium erinaceus
"The mechanisms of neuroprotection were through the improvement of antioxidant, mitochondrial function and anti-apoptosis." (2019) Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia
"...the majority of preclinical data strongly suggests that it is safe and offers much-needed neuroprotective applications." (2018) Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines
"Over the past decade, it has been demonstrated that H. erinaceus polysaccharides possess various promising bioactivities, including antitumor and immunomodulation, anti-gastric ulcer, neuroprotection and neuroregeneration, anti-oxidation and hepatoprotection, anti-hyperlipidemia, anti-hyperglycemia, anti-fatigue and anti-aging."
(2017) Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom: A review
"The reported health-promoting properties of the mushroom fruit bodies, mycelia, and bioactive pure compounds include antibiotic, anticarcinogenic, antidiabetic, antifatigue, antihypertensive, antihyperlipodemic, antisenescence, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties and improvement of anxiety, cognitive function, and depression." (2015) Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds
Hericium erinaceus- an edible mushroom with medicinal values
Effects of cultivation techniques and processing on antimicrobial and antioxidant activities of Hericium erinaceus
Compounds for dementia from Hericium erinaceum
Reversal of cognitive decline: A novel therapeutic program
Hericenones and erinacines- stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus
Reduction of depression and anxiety after 4 weeks of Lion's Mane intake
Functional Recovery Enhancement Following Injury to Rodent Peroneal Nerve by Lion’s Mane Mushroom, Hericium erinaceus
Hypoglycemic effect of extract of Hericium erinaceus
The influence of Hericium erinaceus extract on myelination process in vitro
Protective Effects of Hericium erinaceus Mycelium and Its Isolated Erinacine A against Ischemia-Injury-Induced Neuronal Cell Death
Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress
Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies
Cyanthin Diterpenoid and Sesterterpene Constituents of Hericium erinaceus Mycelium Ameliorate Alzheimer’s Disease-Related Pathologies
Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain